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Collagen production : The Most Important Factor The skin is the largest organ of the body that protects our internal tissues from chemical, physical, and microbial damage. It also helps to prevent loss of water and other endogenous substances, participates in thermoregulation of the body and serves as an excretory organ. The skin is differentiated into the epidermis, dermis and subcutaneous layers. The external non-vascularized layer, the epidermis, consists of differentiating keratinocytes that overlay a basement membrane, melanocytes and Langerhans cells, and serves as the main semipermeable protective barrier. The dermis, below the basement membrane, consists of fibroblasts, nerves, hair follicles, sebaceous glands, sweat glands, lymphatic and blood vessels. The dermal layer gives shape, firmness, sensation and nourishment to the skin. Finally, the subcutaneous layer consists mostly of adipose tissue, acting primarily as a heat insulator and a mechanical cushion.
With age, the skin undergoes vast changes, becoming wrinkled and rigid, losing its firmness, elasticity, tone, texture, thickness, flexibility and moisture content. Skin aging is attributed to several changes. These include alterations in the dermal extracellular matrix (ECM) made up mainly by collagen (which provides strength and structure) and elastin (which provides elasticity and resilience) fibres. Collagen and elastin are secreted mostly by fibroblasts. Transforming growth factor- β (TGF-β) is the primary stimulator of the collagen and elastin fiber formation and deposition, and plays a significant role in scar formation
Copper has two key properties that endow it as an excellent active ingredient to be used in products, which come in contact with the skin, aiming to improve the skin’s well-being. Copper plays a key role in the synthesis and stabilization of skin proteins, and it also has potent biocidal properties.” …
It promotes collagen production.
Collagen is a naturally occurring protein that depletes over time. Lower levels of collagen can lead to fine lines and wrinkles.
Vitamin C is well known for boosting collagen production through the process of collagen synthesis. In fact, collagen synthesis can’t happen without vitamin C..This is because vitamin C is the essential cofactor for the two enzymes required for collagen synthesis:
prolyl hydroxylase, which stabilizes the collagen molecule.
lysyl hydroxylase, which provides structural strength.
Collagen production is tied to skin elasticity and firmness. When your collagen levels begin to drop, your skin may also begin to sag. Applying a vitamin C serum may boost collagen production, resulting in an overall tightening effect, reports a 2017 review. This is true for sagging due to natural aging, oxidative stress damage, or extreme weight loss. This means it can help reduce the appearance of sagging skin, making your skin look firmer and more toned.
Vitamin C (Ascorbic Acid), the antiscorbutic vitamin, cannot be synthesized by humans and other primates, and has to be obtained from diet. Ascorbic acid is an electron donor and acts as a cofactor for fifteen mammalian enzymes. Two sodium-dependent transporters are specific for ascorbic acid, and its oxidation product dehydroascorbic acid is transported by glucose transporters. Ascorbic acid is differentially accumulated by most tissues and body fluids. Plasma and tissue vitamin C concentrations are dependent on amount consumed, bioavailability, renal excretion, and utilization. To be biologically meaningful or to be clinically relevant, in vitro and in vivo studies of vitamin C actions have to take into account physiologic concentrations of the vitamin.
Copper ions are essential for the action of Vitamin C on skin. We can get Copper ions from homeopathic medicine cuprum metallicum 6CH potency (source of Copper ions) which act with homeopathic medicine Acidum Ascorbicum in 6CH potency (Source of Vitamin C ions) which will act on collagen fibres protein of skin thereby tightening the skin.
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