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by Dr Umang Khanna (BHMS)
Fever, or pyrexia, is the elevation of an individual’s core body temperature above a ‘set-point’ regulated by the body’s thermoregulatory center in the hypothalamus. This increase in the body’s ‘set-point’ temperature is often due to a physiological process brought about by infectious causes or non-infectious causes such as inflammation, malignancy, or autoimmune processes. These processes involve the release of immunological mediators, which trigger the thermoregulatory center of the hypothalamus, leading to an increase in the body’s core temperature.
The normal temperature of the human body is approximately 37 degrees Celsius (C), or 98.6 degrees Fahrenheit (F), and varies by about 0.5 C throughout the day. This variation in the core body temperature results from normal physiological processes throughout the human body, including metabolic changes, sleep/wake cycles, hormone variability, and changing activity levels. However, in the case of a fever, the increase in the core body temperature is often greater than 0.5 C and is attributed to a fever-inducing substance (pyrogen).
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